Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Prabhakar V
SVR Engineering College,
Ananthapuramu (JNTU-A), Nandyal-518 502, Kurnool District, Andhra Pradesh
India
Research Article
Synthesis, Characterisation and Biological Evaluation of Quinazoline Derivatives as Novel Anti-Microbial Agents
Author(s): Prabhakar V, Sudhakar BK, Ravindranath LK, Latha J, Venkateswarlu BPrabhakar V, Sudhakar BK, Ravindranath LK, Latha J, Venkateswarlu B
A novel series of Quinazolines were synthesised by cyclisation reaction of Anthranilic acid with urea to get 2,4 di hydroxy quinazoline (2) intermediate, which were further treated with POCl3 to get 2,4 di chloro quinazoline (3), which was treated with Thio-morpholine (4) for 3 hrs to get compounds (5), which are reacted with aqueous ammonia to get compound(6), which was further reacts with different boronic acids 7(a-j) by using Chan-Lam coupling reaction conditions to get Target Novel Quinazoline derivatives (8a-8j). The structures of new compounds were confirmed by IR and 1H NMR and 13C NMR spectral data. Anti-bacterial and anti-fungal activities were evaluated and compared with the standard drugs, compounds 8i, 8d, 8h, 8g exhibited promising anti-microbial and anti-fungal activity compared to standard drugs... View More»