Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Pradeep AR
Seribiotech Research Laboratory, CSB-Kodathi Campus,
Carmelaram P.O Bangalore – 560035, Karnataka
India
Research Article
Phylogeny of Host Response Proteins Activated in Silkworm Bombyx mori in Response to Infestation by Dipteran Endoparasitoid Revealed Functional Divergence and Temporal Molecular Adaptive Evolution
Author(s): Pradeep AR, Anitha J, Panda A, Pooja M, Awasthi AK, Geetha NM, Ponnuvel KM and Trivedy KPradeep AR, Anitha J, Panda A, Pooja M, Awasthi AK, Geetha NM, Ponnuvel KM and Trivedy K
Heterogeneous group of 19 host – response proteins were activated in commercially important silkworm, Bombyx mori after infestation by dipteran parasitoid, Exorista bombycis. The proteins include components of Toll and melanisation pathways, autophagy and apoptosis regulators, chaperones, cytokines and proteolytic enzymes. We elucidated phylogenetic relation within each host – response proteins belong to different insect orders. Multiple sequence alignment with most similar sequences showed large proportion of amino acid conservation in stress proteins, melanisation components, cactus, chitinase and autophagy 5 – like whereas signal proteins and cytokines showed ~30 % amino acid conservation. Phylogenetic analysis of the proteins revealed divergence which is an adaptive mechanism to provide immunity against parasitic attacks. In order to analyz.. View More»
DOI:
10.4172/2155-9899.1000370