Journal of Proteomics & Bioinformatics
Open Access

Premendu P. Mathur

Publications

• Research Article
  A Signaling Network of Thyroid-Stimulating Hormone
  Author(s): Renu Goel, Rajesh Raju, Jagadeesha Maharudraiah, Ghantasala S. Sameer Kumar, Krishna Ghosh, Amit Kumar, T. Pragna Lakshmi, Jyoti Sharma, Rakesh Sharma, Lavanya Balakrishnan, Archana Pan, Kumaran Kandasamy, Rita Christopher, V. Krishna, S. Sujatha Mohan, H. C. Harsha, Premendu P. Mathur, Akhilesh Pandey and T. S. Keshava PrasadRenu Goel, Rajesh Raju, Jagadeesha Maharudraiah, Ghantasala S. Sameer Kumar, Krishna Ghosh, Amit Kumar, T. Pragna Lakshmi, Jyoti Sharma, Rakesh Sharma, Lavanya Balakrishnan, Archana Pan, Kumaran Kandasamy, Rita Christopher, V. Krishna, S. Sujatha Mohan, H. C. Harsha, Premendu P. Mathur, Akhilesh Pandey and T. S. Keshava Prasad
  
  Human thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland. TSH plays an important physiological role in the regulating the hypothalamic-pituitary-thyroid axis by modulating the release of the thyroid hormones from the thyroid gland. It induces iodine uptake by the thyroid, promotes thyroid epithelial differentiation and growth, and protects thyroid cells from apoptosis. Impairment of TSH signal transduction pathway leads to thyroid disorders such as goitre, hypothyroidism and hyperthyroidism, which can have complex clinical manifestations. TSH signaling is largely effected through two separate pathways, the adenylate cyclase and the phospholipase C pathways. In spite of its biomedical importance, a concise signaling map of TSH pathway is not available in the public domain. Therefore, we have generated a detailed signaling map of TSH.. View More»
  DOI: 10.4172/jpb.1000195

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