Journal of Cell Signaling
Open Access
ISSN: 2576-1471
+44 1223 790975
ISSN: 2576-1471
+44 1223 790975
Qingzhi Ma
China
Review
The Relationship between Mitochondria Ca2+ Intake Mediated by Mitochondria-associated Endoplasmic Reticulum Membranes and Tumor Genesis
Author(s): Zijian Zhu, Qingzhi Ma, Qian Wang, Xiacheng Sun, Zhanhua Zhang, Lele Ji and Qichao HuangZijian Zhu, Qingzhi Ma, Qian Wang, Xiacheng Sun, Zhanhua Zhang, Lele Ji and Qichao Huang
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are regions of the endoplasmic reticulum (ER) tethered to mitochondria, which play a key role in mediating material transfer and signal transduction between the two organelles. The findings from recent studies on MAMs contributed to deeper understanding of the complexities associated with the structure, the important proteins involved and the intricacies in the related biological pathways. A large number of Ca2+ transporter proteins and their regulatory proteins are located on MAMs, which finely regulate a series of important cellular activities such as mitochondrial Ca2+ homeostasis, ATP production and cell apoptosis. MAMs are also enriched with many oncogenic proteins and tumor suppressor proteins, which are closely related to the regulation of Ca2+ transport. Therefore, the role of MAMs .. View More»