Journal of Drug Metabolism & Toxicology
Open Access

R Pathak

Publications

• Research Article
  Role of Zinc on Antioxidative Enzymes and Lipid Peroxidation in Brain of Diabetic Rats
  Author(s): Ashima Pathak, Abhishek S Rathore, Vimal Bhutani and R PathakAshima Pathak, Abhishek S Rathore, Vimal Bhutani and R Pathak
  
  Background: Diabetes is the third leading cause of death in the United States after heart disease and cancer. It is a chronic and progressive illness that causes considerable morbidity and premature mortality. Research shows that zinc, an essential trace element responsible for over 300 enzyme functions, can aid in normalizing the negative effects of diabetes mellitus. Zinc plays an important role in major metabolic pathways, and also regulates insulin production by pancreatic tissue and glucose utilization by muscle and fat cells. But not many studies have been performed regarding the antioxidative role of zinc on brain during diabetes. Methods: Male Wistar rats were given zinc in the form of ZnSO4 .6H2 O at a dose level of 227 mg/L daily in their drinking water and diabetes was induced by giving a single intraperitoneal injection of alloxan (.. View More»
  DOI: 10.4172/2157-7609.1000122

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