Clinical & Experimental Cardiology
Open Access

Rafael Diniz Abrantes

Publications

• Research Article
  Comparative Analysis of the Effects of Omeprazole and Ischemic Preconditioning in Protection against Ischemia and Reperfusion Myocardial: Experimental Study in Isolated Rat Hearts
  Author(s): Rafael Diniz Abrantes, Otoni Moreira Gomes, Elias Kallás, Alexandre Ciappina Hueb and Melchior Luiz LimaRafael Diniz Abrantes, Otoni Moreira Gomes, Elias Kallás, Alexandre Ciappina Hueb and Melchior Luiz Lima
  
  Introduction: Myocardial protection against ischemic injury has been a major focus of studies of cardiovascular sciences worldwide. In 1986, Murry et al. became pioneers by showing a special ischemic preconditioning technique in hearts of dogs which motivated researches for better understanding of endogenous protective mechanisms of the human heart. The aim of this study was to evaluate the effects of omeprazole on protection of functional recovery of isolated rat hearts subjected to ischemia-reperfusion with and without ischemic preconditioning (IP). Methods: In five groups of eight Wistar breed rats, the hearts were removed after anesthesia and perfused with Krebs-Henseleit solution (95% O2, 5% CO2, 37ºC). The GI was a control group. The GII, GIII, GIV and GV, hearts were submitted to ischemia (20 min) and reperfusio.. View More»
  DOI: 10.4172/2155-9880.1000252

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