Journal of Clinical & Experimental Dermatology Research
Open Access

Raghavan PR

Publications

• Research Article
  Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis
  Author(s): Raghavan PR Raghavan PR
  
  Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune systemsuppressing medications such as methotrexate. The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has .. View More»
  DOI: 10.4172/2155-9554.1000433

  Abstract PDF

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