Gynecology & Obstetrics
Open Access

Rajyashri Sharma

Publications

• Research Article
  Apoptotic Index and Mib-1 Antibody Expression in Premalignant and Malignant Lesions of Uterine Cervix
  Author(s): Kanupriya Gupta, Kiran Alam, Veena Maheshwari, Roobina Khan and Rajyashri SharmaKanupriya Gupta, Kiran Alam, Veena Maheshwari, Roobina Khan and Rajyashri Sharma
  
  Introduction: Cervical cancers are the second most frequent type of female cancer, responsible for about 5% of cancer deaths in females worldwide. Recently, parameters of cell proliferation and cell death have emerged as important diagnostic and prognostic tools. Aims: The aim was to evaluate the role of Apoptotic Index and Ki-67 as proliferation marker in premalignant and malignant lesions of uterine cervix. Materials and Methods: The study included 179 patients of cervical dysplasias and malignancy. Evaluation of Apoptotic Index (using light microscopy) was performed on hematoxylin and eosin-stained sections. Ki-67 (MIB-1 antibody) expression was both graded as well as Labelling Index was calculated. Statistical evaluation was carried out using the Student t test (p<0.05). Results: There was increase in mean Apopt.. View More»
  DOI: 10.4172/2161-0932.1000173

  Abstract PDF

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