Journal of Chromatography & Separation Techniques
Open Access

Ralph Feltens

Publications

• Research Article
  Evaluation of Population and Individual Variances of Urinary Phthalate Metabolites in terms of Epidemiological Studies
  
  Author(s): Ralph Feltens, Stefan Roeder, Wolfgang Otto, Michael Borte, Irina Lehmann, Martin von Bergen and Dirk K. Wissenbach Ralph Feltens, Stefan Roeder, Wolfgang Otto, Michael Borte, Irina Lehmann, Martin von Bergen and Dirk K. Wissenbach
  
  In the context of an epidemiological study, urinary concentrations of nine phthalic diester metabolites (monoethyl-, mono-(3-carboxypropyl)-, mono-n-butyl-, monoisobutyl-, monobenzyl-, mono-(2-ethylhexyl)-, mono-(5-hydroxy-2- ethylhexyl)-, mono-(5-oxo-2-ethylhexyl)- and mono-(5-carboxy-2-ethylpentyl)-phthalate) were quantified via LC-MS/ MS. As in the majority of epidemiological studies only single spot samples were available for urine analysis, the implicit assumption in this case is, that exposure data obtained from single spot samples are representative for a longer exposure period. To validate the relevance of single spot analyses we quantified the respective intra-individual variances of urine samples collected from ten volunteers once daily over a period of 30 days. Using the values for the daily variances, approximate values for the underlying population variances in the cohort.. View More»
  DOI: 10.4172/2157-7064.1000290

  Abstract

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