Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Ramos S
National Centre for Neuroimmunology and Emerging Diseases, NCNED,
Gold Coast, Queensland
Australia
Research Article
Characterisation of B cell Subsets and Receptors in Chronic Fatigue Syndrome Patients
Author(s): Ramos S, Brenu E, Nuyen T, Ng J, Staines D and Marshall-Gradisnik SRamos S, Brenu E, Nuyen T, Ng J, Staines D and Marshall-Gradisnik S
Limited immunological changes have been previously reported in B cell phenotype in Chronic Fatigue Syndrome (CFS) patients, so there is no clear established role of B cells in the pathophysiology of CFS patients. The aim of this study was to evaluate B cells subsets including naive, memory naive, memory switched, memory non-switched, double negative, transitional, plasmablasts, HLA-DR+, plasma and regulatory B cells (Breg) in CFS patients compared with non-fatigued controls. B cell activation markers (CD81, CD21) and surface receptors (CD79a/b, IgM, IgD, IgA, IgE) were also examined in CFS patients compared with non-fatigued controls. 46 CFS patients (age=50.00 ± 2.00 years) and 34 non-fatigued controls (age=49.00 ± 2.16 years) participated in the study. The percentage of BCR IgM+ B cells was significantly increased in the CFS group compa.. View More»
DOI:
10.4172/2155-9899.1000288