Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Rana Bitar
Lebanon
Research Article
Histopathological Effects of the Annona muricata Aqueous Leaves Extract on the Liver and Kidneys of Albino Mice
Author(s): Rana Bitar, Rajaa Fakhoury, Ragaee Fahmi and Jamilah Borjac*Rana Bitar, Rajaa Fakhoury, Ragaee Fahmi and Jamilah Borjac*
Annona muricata (AM) is a plant that is traditionally used for its various medicinal benefits. The present investigation aims at estimating the anti-inflammatory activity of AM leaf extract against peritonitis induced by Bacillus furmis. Albino mice (25-30 grams) were intra-peritoneally injected with 1.5 × 109 CFU Bacillus furmis and treated with either AM water extract (100 mg/kg) or combination of AM and aspirin. Control groups received only water. Mice were pre-treated with AM extract either two hours or 7 days prior to bacterial infection. Animals were sacrificed three days after bacterial infection. Livers and kidneys were removed and preserved in 10% formalin solution for histopathological studies or in Carnoys solution to assess level of glycogen in liver. The histopathological studies of animals treated with 100 mg/kg AME and 100 mg/kg aspirin showed a synergistic anti-in.. View More»
DOI:
10.4172/2161-1025.1000194