Journal of Clinical and Cellular Immunology
Open Access

Rüdiger Hardeland

Publications

• Mini Review
  Brain Inflammaging: Roles of Melatonin, Circadian Clocks and Sirtuins
  Author(s): Rüdiger Hardeland Rüdiger Hardeland
  
  Inflammaging denotes the contribution of low-grade inflammation to aging and is of particular importance in the brain as it is relevant to development and progression of neurodegeneration and mental disorders resulting thereof. Several processes are involved, such as changes by immunosenescence, release of proinflammatory cytokines by DNA-damaged cells that have developed the senescence-associated secretory phenotype, microglia activation and astrogliosis because of neuronal overexcitation, brain insulin resistance, and increased levels of amyloid-β peptides and oligomers. Melatonin and sirtuin1, which are both part of the circadian oscillator system share neuroprotective and anti-inflammatory properties. In the course of aging, the functioning of the circadian system deteriorates and levels of melatonin and sirtuin1 progressively decline. Protective effects of melatonin and sirt.. View More»
  DOI: 10.4172/2155-9899.1000543

  Abstract PDF

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