Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Rebecca L. Klug
Tanzania
Review Article
Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis
Author(s): Dana L. Sharma, Hari Vishal Lakhani, Rebecca L. Klug, Brian Snoad, Rawan El-Hamdani, Joseph I. Shapiro and Komal Sodhi*Dana L. Sharma, Hari Vishal Lakhani, Rebecca L. Klug, Brian Snoad, Rawan El-Hamdani, Joseph I. Shapiro and Komal Sodhi*
Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by a steatosis of the liver that may progress to more serious pathological conditions including: nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. As the prevalence of NAFLD has increased worldwide in recent years, pathophysiology and risk factors associated with disease progression of NAFLD are at the focus of many studies. NAFLD is related to and shares common serum biomarkers with cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome (MetS). West Virginia (WV) is a state with some of the highest rates of CVD, obesity and diabetes mellitus. As NAFLD is closely related to these diseases, it is of particular interest in WV. Currently there is no cost-effective, standardized method used clinically to detect NAFLD prior to the onset of reversible complications. At th.. View More»
DOI:
10.4172/2155-9899.1000523