Journal of Clinical and Cellular Immunology
Open Access

Rebecca M. Sappington

Publications

• Short Communication
  Interleukin-6: A Constitutive Modulator of Glycoprotein 130, Neuroinflammatory and Cell Survival Signaling in Retina
  Author(s): Franklin D. Echevarria, Abigayle E. Rickman and Rebecca M. Sappington Franklin D. Echevarria, Abigayle E. Rickman and Rebecca M. Sappington
  
  Objective: The interleukin-6 (IL-6) family of cytokines and their signal transducer glycoprotein (gp130) are implicated in inflammatory and cell survival functions in glaucoma. There are several avenues for interdependent modulation of IL-6 family members and gp130 signaling. Here we investigated whether IL-6 modulates gp130 and related neuroinflammatory, cell survival and regulatory signaling in both healthy and glaucomatous retina. Methods: In naïve and glaucomatous (Microbead Occlusion Model), wildtype (WT) and IL-6 knockout (IL-6-/-) mice, we examined gp130 protein expression and localization, using western blot and immunohistochemistry. Gene targets related to IL-6 and gp130 signaling and pertinent to neuroinflammation (TNFα, IL-1β), cell health (Bax, Bcl-xl) and STAT3 regulation (Socs3) were quantified using qRTPC.. View More»
  DOI: 10.4172/2155-9899.1000439

  Abstract PDF

Relevant Topics