Biochemistry & Pharmacology: Open Access
Open Access

Richard Madsen

Publications

• Research Article
  Determination of Kanamycin Plasma Levels Using LC-MS and Its Pharmacokinetics in Patients
  Author(s): Pierre Mugabo, Mercy I Abaniwonda, Danie Theron, Leonie Van Zyl, Shafick M Hassan, Marietjie Stander, Helen McIlleron and Richard Madsen Pierre Mugabo, Mercy I Abaniwonda, Danie Theron, Leonie Van Zyl, Shafick M Hassan, Marietjie Stander, Helen McIlleron and Richard Madsen
  
  Purpose: The objectives of the study were: (1) to determine kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC-MS), (2) to investigate kanamycin pharmacokinetics (PK) in patients with multi-drug resistant tuberculosis (MDR-TB), (3) to find out whether HIV infection, kidney dysfunction and antiretroviral drugs influence kanamycin PK. Methods: The study was designed as a non-randomized study involving male and female HIV- positive and HIV negative patients admitted for MDR-TB treatment. Blood samples were collected before (baseline) and ½, 1, 2, 4, 8 and 24 hours after intramuscular injection of kanamycin. LC-MS was used to quantify kanamycin plasma concentrations. Results: Thirty one patients including 13 HIV (+) participated in the study. The lower limit of detecti.. View More»
  DOI: 10.4172/2167-0501.1000160

  Abstract PDF

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