Lupus: Open Access
Open Access

Richardson BC

Publications

• Research Article
  Oxidative T Cell Modifications in Lupus and Sjogren’s Syndrome
  Author(s): Strickland FM, Mau T, O’Brien M, Ghosh A, Richardson BC and Yung RStrickland FM, Mau T, O’Brien M, Ghosh A, Richardson BC and Yung R
  
  Objectives: Lupus flares are triggered by environmental agents that cause oxidative stress, but the mechanisms involved are unclear. The flares are characterized by oxidative modifications of proteins by 4-hydroxynonenals, malondialdehydes, carbonyls and nitration. These modifications have been proposed to induce and perpetuate lupus flares by “altered self” mechanisms. An epigenetically altered CD4+CD28+T cell subset, caused at least in part by nitration of T cell signaling molecules, is found in patients with active lupus, and nitrated T cells are sufficient to cause lupus-like autoimmunity in animal models. The relation of protein 4-hydroxynonenals, malondialdehydes, carbonyls and nitration to lupus flares though, is unknown. We tested if the size of the epigenetically altered subset is related to disease activity and one or more of these oxidative modi.. View More»
  DOI: 10.35248/2684-1630.17.2.121

  Abstract PDF

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