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Open Access

Rinki Kumari Verma

Publications

• Research Article
  In Vivo Evaluation of the Antidepressant Activity of a Novel Polyherbal Formulation
  Author(s): Rinki Kumari, Aruna Agrawal, Ilango K, Singh GPI and Dubey GP Rinki Kumari, Aruna Agrawal, Ilango K, Singh GPI and Dubey GP
  
  Background: The present study was undertaken to evaluate the anti-depressive activity of a polyherbal formulation (PF) after 28 days administration by using a rat forced swimming test (FST) and tail suspension test (TST). Methods: Animals were divided into six groups (n=6/group): Group 1: The control rats received injections of 0.5% CMC solution only; Group 2: FST+vehicle; Groups 3: FST+SER (10 mg/kg, i.p.); Group 4: FST+200 mg/kg; Group 5: FST+400 mg/kg; Group 6: FST+800 mg/kg and drugs were administrated once daily for 28 days treatment. To assess the effect of PF on immobility activity through FST and TST were used to take as a measure of antidepressant activity. The probable mechanism of action of the anti-depressive effect of PF was also investigated by measuring the level of serotonin, dopamine, norepinephrine, homocysteine, IL-2 and I.. View More»
  DOI: 10.4172/2165-7890.1000194

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