Journal of Clinical and Experimental Ophthalmology
Open Access

Rishi P. Singh

Publications

• Research Article
  Evaluation of Microcollimated Pars Plana External Beam Radiation in the Porcine Eye
  Author(s): Rishi P. Singh, Mark Shusterman, Darius Moshfeghi, Tom Gardiner and Michael GertnerRishi P. Singh, Mark Shusterman, Darius Moshfeghi, Tom Gardiner and Michael Gertner
  
  Purpose: To evaluate the clinical and histological side effects of a prototype stereotactic radiotherapy system delivering microcollimated external beam radiation through pars plana in porcine eyes.   Methods: Five Yucatan mini-swine (10 eyes) were randomized to five treatment groups. Eight eyes were dosed with X-ray radiation on Day 1, and two eyes served as untreated controls. Treated eyes received doses up to 60 Gy to the retina and up to 130 Gy to the sclera using single or overlapping beams. The treatment beams were highly collimated such that the diameter was approximately 2.5 mm on the sclera and 3 mm on the retinal surface. Fundus photography, fluorescein angiography (FA), and spectral domain optical coherence tomography (SD-OCT) were obtained on days 7, 30, 60, and 110. Images were examined by a masked grader and evaluated fo.. View More»
  DOI: 10.4172/2155-9570.1000134

  Abstract PDF

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