ISSN: 2155-9600
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Rivera María del P
Mexico
Commentary
The Antioxidant Activity of Peptides Isolated from Amaranthus on Normal
Human Skin in vitro and Inflammatory Cytokines Detection
Author(s): Alcántara Quintana LE, Ortiz Hernández A, Rivera María del P and Soriano Santos J
Alcántara Quintana LE, Ortiz Hernández A, Rivera María del P and Soriano Santos J
Oxidative stress has been implicated in various skin diseases through the generation of reactive oxygen species and the depletion of endogenous antioxidant systems. Evidence exists indicating that oxidative stress injury of the skin caused by UVB irradiation is mediated predominantly by reactive oxygen species (ROS) immediately after irradiation and by reactive nitrogen species (RNS) at later points. We investigated the protective effect of peptides (albumin and hydrolysates) isolated from Amaranthus (pA) against UVB irradiation, lipid peroxidation (malondialdehyde, MDA) and endogenous antioxidant defense enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). Supernatant levels of pro-inflammatory and anti-inflammatory cytokines were also investigated. We used human skin organ culture as an in vitro model via 24, .. View More»
DOI:
10.4172/2155-9600.1000419