Journal of Medical & Surgical Pathology
Open Access

Rob AEM Tollenaar

Publications

• Research Article
  Stroma-High Lymph Node Involvement Predicts Poor Survival More Accurately for Patients with Stage III Colon Cancer
  Author(s): Gabi W van Pelt, Torben F Hansen, Esther Bastiaannet, Sanne Kjær-Frifeldt, J Han JM van Krieken, Rob AEM Tollenaar, Flemming B Sørensen, Wilma E Mesker Gabi W van Pelt, Torben F Hansen, Esther Bastiaannet, Sanne Kjær-Frifeldt, J Han JM van Krieken, Rob AEM Tollenaar, Flemming B Sørensen, Wilma E Mesker
  
  Objective: The tumor microenvironment has ample impact on the behavior of the malignant process in colon cancer (CC). Patients with a high percentage of stroma within the primary tumor, determined by the tumor-stroma ratio (TSR), have a poor prognosis. In metastatic lymph nodes from patients with stage III CC, the TSR is heterogeneous, but the impact on patients’ prognosis is unknown. Methods: Haematoxylin and eosin stained tissue slides of primary tumor (PT) and associated lymph nodes (LNs) metastases from 102 patients with stage III CC were analyzed for the TSR. Stroma-high (>50% stroma) and stromalow (≤ 50% stroma) groups were evaluated with respect to disease free survival (DFS). Results: Of 102 analyzed primary tumors, 47 (46.1%) scored as stroma-high and 55 (53.9%) as stroma-low. In total, 33 patients h.. View More»
  DOI: 10.4172/2472-4971.1000116

  Abstract PDF

Relevant Topics