Journal of Developing Drugs
Open Access

Robert A Lodder

Publications

• Research Article
  DDDAS Design of Drug Interventions for the Treatment of Dyslipidemia in ApoE-/- Mice
  Author(s): Brittney Metts, Sean Thatcher, Eboni Lewis, Mike Karounos, Lisa Cassis, Rebecca Smith and Robert A Lodder Brittney Metts, Sean Thatcher, Eboni Lewis, Mike Karounos, Lisa Cassis, Rebecca Smith and Robert A Lodder
  
  Computational models of complex systems, such as signaling networks and biological systems, can be used to explain the behavior of such systems under various conditions. The large number of integrated processes and variables, and the nonlinearities inherent in the fundamental processes, make it difficult for scientists unassisted by computer simulations to effectively predict the consequences of a particular intervention. For this reason, computer simulation has become an important tool for generating hypotheses about the behavior of these systems that can then be tested in the laboratory and clinic. A dynamic data-driven application simulation (DDDAS) was designed by Biospherics to model complex metabolic disease pathways by testing potential binary therapies in simulations at various combinations of two points in the pathways. Since DDDAS chooses the most effective pair-wise combina.. View More»
  DOI: 10.4172/2329-6631.1000107

  Abstract PDF

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