Clinical & Experimental Cardiology
Open Access

Robert A. Clough

Publications

• Research Article
  Off-pump Coronary Artery Bypass Does Not Influence Biomarkers of Brain Injury, But Does Exacerbate the Systemic Inflammatory Response
  Author(s): Jeremiah R. Brown, Felix Hernandez, Peter A. Beaulieu, Robert A. Clough, Cynthia M. Whited, John D. Klemperer and Donald S. Likosky Jeremiah R. Brown, Felix Hernandez, Peter A. Beaulieu, Robert A. Clough, Cynthia M. Whited, John D. Klemperer and Donald S. Likosky
  
  Background: The protective effects of off-pump (OPCAB) compared to conventional (CCAB) coronary artery bypass graft surgery on neurological injury and inflammation has been controversial. We evaluated pre- and postoperative levels of the brain injury marker, S100β, and markers of inflammation, Interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) in a prospective randomized controlled trial. Methods: A sub-group sample of the randomized controlled trial of 50 consecutive randomized patients (n=27 CCAB, n=23 OPCAB) was utilized for the present biomarker analysis. Each patient had blood drawn before and after surgery. Analysis of variance and Kruskal-Wallis were used to assess significant differences in biomarkers. Results: There was no difference in post-procedure S100β (p=0.1) or change in S100&.. View More»
  DOI: 10.4172/2155-9880.S2-001

  Abstract PDF

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