Journal of Leukemia
Open Access
ISSN: 2329-6917
+44 1300 500008
ISSN: 2329-6917
+44 1300 500008
Robert Weil
Unité de Signalisation Moléculaire et Activation Cellulaire,
CNRS URA 2582, Institut Pasteur, 75724 Paris Cedex 15
France
Review Article
Dysregulation of the antigen-induced NF-κB signaling pathway in the development of human B-cells lymphomas
Author(s): Nassima Messali, Pierre Genin and Robert Weil
Nassima Messali, Pierre Genin and Robert Weil
The adaptive immune response is initiated when microbial or tumor-specific molecules are recognized by antigen receptors present at lymphocyte cell surface. Engagement of these immunoreceptors induces signaling cascades that ultimately activate the transcription factors NF-?B (Nuclear Factor-?B) and NFAT (nuclear factor of activated T-cells) responsible for the establishment of gene expression programs controlling the stimulation, proliferation and survival of activated lymphocytes. Cloning the products of three distinct translocation events found in lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) led to the identification and characterization of a novel NF-?B-activating complex following antigenic stimulation composed by the ARMA1, BCL10, and MALT1 proteins and called the CBM complex. Since the identification of this complex, other regulatory components were discovered whi.. View More»
DOI:
10.4172/2329-6917.1000105