Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Roger S Holmes
Griffith Institute for Drug Discovery and School of Natural Sciences,
Nathan, QLD, 4111
Australia
Research Article
Comparative and Evolutionary Studies of Vertebrate Extracellular Sulfatase Genes and Proteins: SULF1 and SULF2
Author(s): Roger S HolmesRoger S Holmes
Extracellular sulfatases (SULF1; SULF2) (EC: 3.1.6.-) are members of the sulfatase enzyme family which exhibit endoglucosamine-6-sulfatase activity and carry out essential roles in proteoglycan metabolism. These enzymes regulate a number of critical signalling pathways and the sulfation state of glycoaminoglycans in the extracellular space. SULF1 and SULF2 amino acid sequences and structures and SULF-like gene locations were examined using bioinformatic data from several genome projects. Sequence alignments and conserved secondary structures and key amino acid residues and domains were studied. Comparative genomic analyses were conducted using the UC Santa Cruz Genome Browser. Phylogeny studies investigated the evolutionary relationships of these genes and proteins. Human and other vertebrate SULF1 and SULF2 sequences were conserved, including signal peptides, metal (Ca2+) and substra.. View More»
DOI:
10.4172/jpb.1000423