Andrology-Open Access

Andrology-Open Access
Open Access

ISSN: 2167-0250

+44 1300 500008

Rosália Sá

Rosália Sá
Laboratory of Cell Biology, Multidisciplinary Unit for Biomedical Research (UMIB), Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto (UP),
Porto
Portugal

Publications

  • Research Article
    Assessing Male Reproductive Toxicity during Drug Development
    Author(s): Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa

    Pharmaceutical development is a crucial research field that attends to the population healthcare needs, comprising several preclinical and clinical steps before the approval of a new compound. Interestingly, the lack of efficacy and toxicity are known major failure causes during pharmaceutical drug development. Toxicity screening is therefore a mandatory procedure during pharmaceutical development. Renal and hepatic toxicity are the most common toxicity matters encountered during the development of new compounds. Nonetheless, the male reproductive system may also be a target for drug toxicity. However, developmental and reproductive toxicology testing is rarely performed both in pre-clinical and clinical trial phases. As a result, there are several risks for human fertility brought on by putative toxic chemical compounds. As there is a low incidence of reproductive and testicular toxi.. View More»
    DOI: 10.4172/2167-0250.1000185

    Abstract PDF

Relevant Topics

Top