Journal of Clinical Trials
Open Access

Rosalina Barroso

Publications

• Research Article
  Nasal Bilevel Versus Continuous Positive Airway Pressure in Preterm Infants: A Randomized Controlled Trial
  Author(s): Teresa Aguiar, Israel Macedo, Olga Voutsen, Pedro Silva, José Nona, Carina Araujo, Joana Imaginário, Antonio Mauricio, Rosalina Barroso, Teresa Tomé and Helena Carreiro Teresa Aguiar, Israel Macedo, Olga Voutsen, Pedro Silva, José Nona, Carina Araujo, Joana Imaginário, Antonio Mauricio, Rosalina Barroso, Teresa Tomé and Helena Carreiro
  
  Objective: We designed a study with a primary objective of comparing the effectiveness of nasal continuous positive airway pressure (nCPAP) versus bi-level CPAP (BiPAP) as the primary mode of non-invasive ventilation in preterm newborns. The primary outcome was need for invasive ventilation in the first 120 hours of life. The secondary objective was to compare these two groups regarding duration of non-invasive ventilation, use of surfactant, incidence of pneumothorax, bronchopulmonary dysplasia (BPD), peri and intraventricular haemorrhage (PIVH), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), sepsis, length of hospitalisation and mortality. Methods: Prospective, multicentre clinical trial enrolling 220 neonates born at 27 to 32+6 weeks of gestation randomly assigned at birth for either CPAP or BiPAP. Results: One hundred and nine neonates received NC.. View More»
  DOI: 10.4172/2167-0870.1000221

  Abstract PDF

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