Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Roshan Kumar Singh
India
Review Article
Implication of Epigenetic Modifications in Neurodegenerative Disorders: Traces and Imprints
Author(s): Roshan Kumar Singh, Sandeep Satapathy, Abhilasha Singh and Kashyap Bhuyan
Roshan Kumar Singh, Sandeep Satapathy, Abhilasha Singh and Kashyap Bhuyan
Neurodegenerative disorders like Alzheimer’s, Parkinson’s, Huntington’s and ALS; present a complex biological disorder resulting loss of synaptic connections, neuronal damage and decay in old and elderly persons. Such a degrading process of neurons affects the central nervous system and results in loss of cognitive abilities, memory, sensory abilities and impairs the motor neuron functions. Thus, understanding the biology of neurodegenerative diseases has been crucial in ensuring healthy aged life. Although several cases of familial neurodegenerative disorders have been reported, yet the mechanism for sporadic neuronal degeneration remains largely unknown. Therefore, in this review we aim to understand the role of environmental triggers, i.e. epigenetics in affecting the normal functioning and coordination of host nervous system. A distinct signature mark of neurodeg.. View More»
DOI:
10.4172/2155-9899.1000461