Endocrinology & Metabolic Syndrome
Open Access

Rovelli F

Publications

• Review Article
  A Review on Cancer Progression - Related Pineal Endocrine Deficiency: Possible Mechanisms and Clinical Implications
  Author(s): Lissoni P and Rovelli F Lissoni P and Rovelli F
  
  Several experimental studies have demonstrated the existence of a natural immunobiological resistance cancer growth, which is mediated by both immune and neuroendocrine mechanism. Moreover, further researches have shown that the pineal gland plays a fundamental role in the natural antitumor resistance, by representing the most important anti-cancer organ in the human body. The anticancer property of the pineal gland is due to the production of several anticancer molecules, including the indole hormone melatonin (MLT), which represent the most investigated pineal hormone, other indoles, such as the 5-methoxytryptamine, and beta-carbolines. MLT has been proven to play anticancer activity through several mechanisms, consisting of cytotoxic antiproliferative action and stimulation of the anticancer immunity, by promoting IL-2 production by T helper lymphocytes and IL-12 secretion by dendr.. View More»
  DOI: 10.4172/2161-1017.1000239

  Abstract PDF

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