Entomology, Ornithology & Herpetology: Current Research
Open Access

Rowland I.S Agbede

Publications

• Review
  Cytochrome P450s in Anopheles gambiae (Diptera: Culicidae) and Insecticide Resistance in Africa: A Mini Review
  Author(s): Balarabe R. Mohammed, Mailafia S, Malang, S. Kawe, Rowland I.S Agbede and Robert D. Finn Balarabe R. Mohammed, Mailafia S, Malang, S. Kawe, Rowland I.S Agbede and Robert D. Finn
  
  Cytochrome P450s are known to be critical for the detoxification and/or activation of xenobiotics such as insecticides in all living organisms including Anopheles gambiae. Many studies have demonstrated the role of P450s in insecticide resistance in A. gambiae. However, little is known about the impact of distribution in the African subcontinent. In this paper therefore, we analyse the P450 clans, the CYP6 family, localisation and function of A. gambiae CYPs, their insecticide substrates, regional distribution in the African continent and their role in insecticide resistance. This investigation from published data revealed that in the Central region; CYP6Z3, CYP6Z1, CYP12F2, CYP6P4, CYP6GA1, CYP6Z3 (Yaoundé, Cameroun) have bendiocarb, DDT and pyrethroids as substrates; in the Eastern region: CYP314A1 and CYP12F1 (Tanzania and Zanzibar) have DDT as a s.. View More»
  DOI: 10.4172/2161-0983.1000200

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