Journal of Clinical & Experimental Dermatology Research
Open Access

Rubens de Sousa Santana

Publications

• Research Article
  Thymus Output of CD4+CD25highTreg+ is Increased in Patients Carrying Leprae Disease
  Author(s): Bruna Luisa Figueirêdo Pierote, Ester Miranda Pereira, Semiramis Jamil Hadad do Monte, Rubens de Sousa Santana, Deylane Menezes Teles e Oliveira, Saara Barros Nascimento and Adalberto Socorro da Silva Bruna Luisa Figueirêdo Pierote, Ester Miranda Pereira, Semiramis Jamil Hadad do Monte, Rubens de Sousa Santana, Deylane Menezes Teles e Oliveira, Saara Barros Nascimento and Adalberto Socorro da Silva
  
  Background: Leprosy is an infectious disease caused by the intracellular pathogen Mycobacterium leprae, which is a microorganism that evades the host’s immune response. The mechanisms regulating immune circumvention are not fully understood. It has been proposed that the pathogen alters the mechanisms regulating the immune response of the host to escape immune surveillance. Thus, regulatory T cells are important immune elements that must be investigated. To escape the immune response using regulatory properties or natural regulatory T cells (nTreg), M. leprae increases the number of nTregs observed in the steady-state. Because nTregs are thymus derived, one way to verify if M. leprae infection induces de novo nTreg cells is to determine the nature of recent thymus emigrant nTregs in leprosy patients and compare the cells to healthy con.. View More»
  DOI: 10.4172/2155-9554.1000316

  Abstract PDF

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