Organic Chemistry: Current Research
Open Access

Ruslan E Kasumov

Publications

• Review Article
  On the Mechano-Chemiosmotic Mechanism of Action of Guanidinies on Functional Activity of Mitochondria and Aging
  Author(s): Eldar A Kasumov, Ruslan E Kasumov and Irina V Kasumova Eldar A Kasumov, Ruslan E Kasumov and Irina V Kasumova
  
  Functional activity of mitochondria in the cell is fully regulated by a complex mixture of dissolved in water substances of the cytosol compound. The concentrations of these substances are different, which is important in processes such as osmoregulation and signaling both of a cell and of mitochondria for ATP synthesis. We studied the action of guanidine on the functional activity of mitochondria. Mitochondria showed a trend to inhibition of oxidative phosphorylation in the presence of different guanidine concentrations. Also, an oscillatory volume changes shrinkage-swelling of mitochondria ¬- are largely abolished and pH changes of incubation medium in addition of ADP are inhibited in the presence of guanidine ion. The mechanism of inhibition of these processes is explained by mechano-chemiosmotic model. In the article, it is discussed that a disruption of the movement of calci.. View More»
  DOI: 10.4172/2161-0401.1000136

  Abstract PDF

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