Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
S Aravindhan
Presidency College,
Chennai 600 005
India
Research Article
Pyrazole Based Inhibitors against Enzymes of Staphylococcus aureus: A
Computational Study
Author(s): G Jagadeesan, Vinodhkumar Vijayakuma, Malathy Palayam, G Suresh, Gunasekaran Krishnaswamy, S Aravindhan and Gunther H PetersG Jagadeesan, Vinodhkumar Vijayakuma, Malathy Palayam, G Suresh, Gunasekaran Krishnaswamy, S Aravindhan and Gunther H Peters
Pyrazole derivatives display a wide variety of biological activities such as antimicrobial, anti-inflammatory and anti-tumor activities. Its biological prominence has intrigued chemists and biologists in recent years to synthesize new pyrazole derivatives as antiviral, antibacterial and anticancer agents. The current study focuses on molecular docking and dynamics studies of pyrazole derivatives against Nucleosidase and DNA gyrase B of Staphylococcus aureus. Molecular docking and dynamics studies reveal that some of these derivatives show better binding abilities than some of the current drugs available on the market.
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DOI:
10.4172/jpb.1000362