Medicinal & Aromatic Plants
Open Access

Saad Sabbar Dahham

Publications

• Research Article
  In Vitro Anti-Cancer and Anti-Angiogenic Activity of Essential Oils Extracts from Agarwood (Aquilaria crassna)
  Author(s): Saad Sabbar Dahham, Yasser M Tabana, Doblin Sandai, Mowaffaq Adam Ahmed and Amin M Shah Abdul Majid Saad Sabbar Dahham, Yasser M Tabana, Doblin Sandai, Mowaffaq Adam Ahmed and Amin M Shah Abdul Majid
  
  Aquilaria crassna (agarwood) has been used in traditional Asian medicine to treat vomiting, rheumatism, asthma, cough and inflammation. Despite the wide range of ethno-pharmacological use of agarwood, its anti-angiogenic effect has not previously been evaluated through systematic studies. Therefore, the aim of this study was to prepare essential oils extracts from the stem bark of A. crassna native to Malaysia, and determine their anti-proliferative and anti-angiogenic activities. Stem bark samples were extracted with 80% ethanol and hydrodistillation methods. The resulting essential oils from both extraction approaches were subjected for cytotoxic activity using four cancer cell lines and one normal cell line. Hydrodistilled essential oils displayed significant cytotoxic effect against HCT 116 cells with the lowest IC50 value calculated (28.0 ± 1.5 μg/mL). Furthermore, we h.. View More»
  DOI: 10.4172/2167-0412.1000256

  Abstract PDF

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