Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Sabine Zeller
Switzerland
Research Article
The IgE-Binding Self-Antigens Tubulin-α and HLA-DR-α are Overexpressed in Lesional Skin of Atopic Eczema Patients
Author(s): Claudio Rhyner, Sabine Zeller, Catharina Johansson, Annika Scheynius and Reto CrameriClaudio Rhyner, Sabine Zeller, Catharina Johansson, Annika Scheynius and Reto Crameri
Background: Atopic eczema is the most common chronic, relapsing, inflammatory skin disorder with an atopic background. Previous studies have shown that IgE-mediated reactivity to self-antigens plays a role in the pathogenesis of the disease. However, the expression of self-antigens associated with atopic eczema in the lesional skin is poorly investigated.Aim of the study: This study was aimed to show that IgE-binding self antigens are over-expressed in atopic eczema lesions. Methods: Tubulin-α and HLA-DR-α, two recently described self-antigens, were stained by immunohistochemistry in skin specimens from chronic and acute atopic eczema lesions, unaffected skin from the same patients or skin from healthy controls.Results: The expression of tubulin-α and HLA-DR-α is up-regulated in atopic eczema lesions co.. View More»
DOI:
10.4172/2155-9899.1000109