Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Sahar Issa Y
Egypt
Research Article
Parenchymatous Toxicity of Tramadol: Histopathological and Biochemical Study
Author(s): Essam Hafez M, Sahar Issa Y and Safaa Abdel Rahman M
Essam Hafez M, Sahar Issa Y and Safaa Abdel Rahman M
Objective: The present study was designed to highlight the toxic impact of tramadol on both biochemical and histopathological aspects in rats' liver, kidney and thyroid gland. Methods: The study was performed on fifty healthy adult male albino rats divided into five groups with ten rats each. (Four experimental and control groups). Five rats (negative control) were kept in a quite non stressful environment, provided with food ad libitum and free access to water. Normal saline (1 ml) was given intramuscularly as placebo in the positive control group (n = 5). Experimental groups (II, III, IV and V) were injected with tramadol intramuscularly equivalent to 12.5 mg, 25mg, 50 mg and 300 mg/kg body weight/day respectively for two weeks. Results: The levels of alanine aminotransferase (ALT), Cardiac treponin I (CTnl), Prothrombin time (PT) and partial thromboplastin time (PTT) in all tra.. View More»
DOI:
10.4172/2329-6488.1000225