Journal of Clinical & Experimental Dermatology Research
Open Access

Saifuddin Sheikh

Publications

• Research Article
  Topical Delivery of Lipid Based Amphotericin B Gel in the Treatment of Fungal Infection: A Clinical Efficacy, Safety and Tolerability Study in Patients
  Author(s): Saifuddin Sheikh, Ateeq Ahmad, Shoukath M Ali, Mahesh Paithankar, Hanmant Barkate, Ranjan C Raval, Kalpesh Shah, Bhavik A Bhavsar, Radha KR, Jayaraman AM, Manish Sharma and Imran Ahmad Saifuddin Sheikh, Ateeq Ahmad, Shoukath M Ali, Mahesh Paithankar, Hanmant Barkate, Ranjan C Raval, Kalpesh Shah, Bhavik A Bhavsar, Radha KR, Jayaraman AM, Manish Sharma and Imran Ahmad
  
  Objectives: A novel topical formulation of lipid based amphotericin B (0.1% amphotericin B Gel) was developed to assess the safety, tolerability and efficacy in adult patients with cutaneous and/or mucocutaneous fungal infection. Methods: Amphotericin B gel was formulated using lipids. In vitro release assay of amphotericin B was measured using paddle apparatus maintained at 37.0° ± 0.5°C. The stability studies of amphotericin B gel were carried out at 2-8°C, 25°C and 40°C. To test the effect of the drug in clinical setting, 100 patients with recurrent case after failure to standard therapy for cutaneous and/or mucocutaneous fungal infection were treated with amphotericin B Gel. The amphotericin B Gel was applied on the affected area twice daily for 14 days in patients with cutaneous fungal infection and for 7 days.. View More»
  DOI: 10.4172/2155-9554.1000248

  Abstract PDF

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