Biochemistry & Pharmacology: Open Access
Open Access

Saima Jadoon

Publications

• Research Article
  DNA Damage by Heavy Metals in Animals and Human Beings: An Overview
  Author(s): Saima Jadoon* and Arif Malik Saima Jadoon* and Arif Malik
  
  Cancer-causing materials are found in air, water and in some other consumer products in the form of heavy metals. Biomedical research has shown that exposure to heavy metals is an important source of DNA damage in human beings and in animals. Heavy metals like iron, copper, chromium, lead, zinc, mercury, nickel etc. and reactive oxygen species enhance peroxidation of lipids and DNA damage. Elements like arsenic, nickel and cadmium are the ambassadors of mutagenic changes in cell. In mammalian cells it was found that DNA single-strand breaks chromosomal aberrations occurred and sister chromatids exchange due to various nickel salts. It is now a well-established fact that cadmium causes cancer in tissues of animals. Exposure to cadmium develops cancer in the prostate gland, kidney, liver and stomach. Through base pair mutation cancer-causing metals damage DNA. However, some heavy metals.. View More»
  DOI: 10.4172/2167-0501.1000235

  Abstract PDF

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