Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Salim A
India
Review Article
Computational Prediction of microRNAs and their Targets
Author(s): Salim A and Vinod Chandra SSSalim A and Vinod Chandra SS
microRNAs (miRNAs) are small single stranded RNAs, having an average length of 22 nucleotides. microRNAs are generated from endogenous hairpinshaped transcripts through post-transcriptional activity. They are found in diverse organisms and play critical roles in gene expression regulations of many essential cellular processes. Different computational methods are currently available for identifying microRNA genes in the genomes of different species, and predict exactly the functional part of the microRNA gene, namely the mature microRNA. The mature microRNA makes base pairing with mRNA, where complementarities exist between them and thus regulate gene expression. This article presents a brief description of microRNA related databases, different approaches for prediction and target gene identification. The methods employed, characteristics, and species addressed in each of publicly avai.. View More»
DOI:
10.4172/jpb.1000320