Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
+44 1300 500008
ISSN: 2157-7013
+44 1300 500008
Sally M Abd-Elmenm
Egypt
Research Article
Evaluation of the Role of Adipose-Derived Stem Cells in the Healing of
Indomethacin-Induced Gastric Ulceration in Rats
Author(s): Sally M Abd-Elmenm, Sahar M Greish, Maha M Atwa and Mohamed Fathelbab
Sally M Abd-Elmenm, Sahar M Greish, Maha M Atwa and Mohamed Fathelbab
Purpose: To study the effect adipose derived stem cells (ADSCs) in a rat model of gastric ulceration.
Methods: 72 albino rats divided into 3 groups: Group N (Negative control), Group D (positive control); and Group T (ADSCs treated group). Six animals of each group were sacrificed 1, 3, 4 and 5 days after ulcer induction. Each stomach was extracted for macroscopical and histopathological assessment. Vascular endothelial growth factor (VEGF), Prostaglandin E2 (PGE2) and polymerase chain reaction (PCR) for human alu sequences in gastric tissue homogenate were done.
Results: ADSCs transplantation improved the histopathology of the gastric tissue in stem cell treated group. Also the result of ulcer index was significantly decreased in stem cell treated group at day 3, 4 and 5 of the study comparing with the indomethacin chal.. View More»
DOI:
10.4172/2157-7013.1000246