Journal of Cell Science & Therapy
Open Access

Samani F

Publications

• Research Article
  Rat Pancreatic Stromal Cells (PSC) affect Differentiation of Human Mesenchymal Stem Cells (hMSC) into Insulin-Producing Cells (IPCs) In vitro
  Author(s): Khoshchehreh R, Ebrahimi M, EslamiNejad MB, Aghdami N, Samani F and Baharvand HKhoshchehreh R, Ebrahimi M, EslamiNejad MB, Aghdami N, Samani F and Baharvand H
  
  The use of different sources of stem cells including embryonic and mesenchymal stem cells is a novel therapy for diabetic’s patients. However the efficiency of differentiation is not enough to complete treatment. An important point in the induction of stem cells into IPCs in vitro is the role of the pancreatic niche (which includes the stromal and epithelial niche). It can physically contact to adjacent cells and influence stem cell behavior via close range signaling. In this respect, we hypnotized that Pancreatic Stromal Cell (PSC) as a fundamental factor of the stromal niche may have an effective role in the generation IPCs (i.e, the efficiency of differentiation and function of newlyformed β-cells) in vitro. Therefore in this study, MSCs derived from umbilical cord (UC-MSCs) vain and bone marrow (BM-MSCs) was selected to differentiate into IPCs in co-culture with rat PSC.. View More»
  DOI: 10.4172/2157-7013.1000130

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