Pancreatic Disorders & Therapy
Open Access

Samantha L Margulies

Publications

• Research Article
  Vitamin D Deficiency in Patients with Pancreatitis: Is Vitamin D Replacement Required?
  Author(s): Zhiyong Han, Samantha L Margulies, Divya Kurian and Mark S Elliott Zhiyong Han, Samantha L Margulies, Divya Kurian and Mark S Elliott
  
  Clinical findings have shown that approximately 40% of patients with pancreatitis, acute or chronic, have severe vitamin D deficiency; this can reach up to 60% of patients with chronic pancreatitis. These findings raise an important question: Is vitamin D deficiency a cause or a result of pancreatitis? The answer(s) to this question is clinically important given that high oral doses of vitamin D supplementation are widely prescribed for individuals with vitamin D deficiency. Considering that there is active conversion of 25(OH)D3 to 1,25(OH)2D3 by activated macrophages in tissues undergoing inflammation, that elevation of the blood levels of 1,25(OH)2D3 levels can cause hypercalcemia, that hypercalcemia can precipitate pancreatitis, that excessive use of vitamin D supplementation can cause acute pancreatitis and that sarcoidosis causes elevated blood levels of 1,25(OH)2D3, hypercalcem.. View More»
  DOI: 10.4172/2165-7092.1000172

  Abstract PDF

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