Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Sami Lakhal
Laboratory of Virology, Veterinary Research Institute of Tunisia,
Rue Djebel Lakhdhar - La Rabta 1006, Tunis –
Tunisia
Commentary
Sera of Human Beings Hosting Durably Viscerotropic Leishmania Species Display Histones- Binding Immunoglobulins: A Feature To Consider When Probing Signatures of Auto-Reactivity?
Author(s): Sami Lakhal and Abdelhak Ben YounesSami Lakhal and Abdelhak Ben Younes
When being asked to extract molecular immune signatures, at the preclinical stage of Systemic Lupus Erythematosus (SLE), the analysts who received the subjects’ blood monitor the presence and titers of autoantibodies against a more or less extended panel of SLE associated autoantigens. Tunisian subjects are known to stably share habitats where zoo anthropophilic blood-feeding sand flies and Leishmania infantum co-perpetuate. We were curious to add three other antigenic sources depicted below. Two serum biobanks were selected in the original publication. Analysis from the second shown, four sera containing high titers of mammalian histones autoantibodies as well as a range of ENA-binding autoantibodies. Combined tests that allow detecting antibodies signing risks of developing SLE as well as exposure to viscerotropic Leishmania species, whenever physicians addressed blood of heal.. View More»
DOI:
10.4172/2155-9899.1000390