Journal of Proteomics & Bioinformatics
Open Access

Sami Mostafa

Publications

• Research Article
  In Vitro and In Vivo Evaluation of Bauhinia variegata Extracts to Prevent Coxsackievirus B3 Infection
  Author(s): Mohamed Shaheen, Maria Borsanyiova, Sami Mostafa, Shubhada Bopegamage and Nagwa El-Esnawy Mohamed Shaheen, Maria Borsanyiova, Sami Mostafa, Shubhada Bopegamage and Nagwa El-Esnawy
  
  Coxsackievirus B3 (CVB3) is one of the most viral agents that cause myocarditis in human, particularly in infants and young children. However, up to date, there are no vaccine or antiviral agents to prevent and/or treat the disease caused by this virus. The aim of this study was to determine the antiviral activities of Bauhinia variegata extracts against CVB3 infection in vitro and in vivo. Five extracts from B. variegate leaves were tested for their antiviral activity against CVB3 in vitro by applying three different strategies using MTT and TCID50 assays. The antiviral activity in vivo was performed by monitoring of morbidity, mortality, the heart index, virus titers, and pathologic scores. In addition, measuring the activities of Aspartate Transaminase (AST), Creatine Kinase (CK), and Lactic Dehydrogenase (LDH) enzymes in infected mice with CVB3. Our results suggested that the meth.. View More»
  DOI: 10.4172/jpb.1000426

  Abstract PDF

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