Rheumatology: Current Research
Open Access

Sami Turki

Publications

• Research Article
  BAFF Promoter Polymorphisms and Serum levels in Tunisian Patients with Systemic Lupus Erythematosus
  Author(s): Imen Sfar, Tarak Dhaouadi, Sami Turki, Lamia Ben Hassine, Adel Khedher, Narjess Khalfallah, Taieb Ben Abdallah and Yousr Gorgi Imen Sfar, Tarak Dhaouadi, Sami Turki, Lamia Ben Hassine, Adel Khedher, Narjess Khalfallah, Taieb Ben Abdallah and Yousr Gorgi
  
  Objectives: To investigate any associations between regulatory genetic polymorphisms of the B-lymphocyte activating factor (BAFF) gene, disease susceptibility and serum soluble BAFF (s-BAFF) levels in Tunisian systemic lupus (SLE) patients. Patients and methods: This case-control study included 124 SLE patients and 152 healthy controls. Three single nucleotide polymorphisms (SNPs) (-2841 T>C, -2701 A>T and -871 C>T) in the 5’ regulatory region of the BAFF gene were explored by PCR-RFLP. Serum BAFF levels were measured by ELISA (R&D Systems®). Results: s-BAFF levels were elevated in SLE patients (1717.08 pg/ml) and in anti-dsDNA positive antibodies patients (1948.28 pg/ml) compared to both controls (665.82 pg/ml, p<10-8) and patients without anti-dsDNA antibodies (1281.51 pg/ml, p=0.007). I.. View More»
  DOI: 10.4172/2161-1149.S4-003

  Abstract PDF

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