Journal of Proteomics & Bioinformatics
Open Access

Samuel G. Mackintosh

Publications

• Research Article
  Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma
  Author(s): Stephanie D. Byrum, Signe K. Larson, Nathan L. Avaritt, Linley E. Moreland, Samuel G. Mackintosh, Wang L. Cheung and Alan J. Tackett Stephanie D. Byrum, Signe K. Larson, Nathan L. Avaritt, Linley E. Moreland, Samuel G. Mackintosh, Wang L. Cheung and Alan J. Tackett
  
  Molecular pathways regulating melanoma initiation and progression are potential targets of therapeutic development for this aggressive cancer. Identification and molecular analysis of these pathways in patients has been primarily restricted to targeted studies on individual proteins. Here, we report the most comprehensive analysis of formalin-fixed paraffin-embedded human melanoma tissues using quantitative proteomics. From 61 patient samples, we identified 171 proteins varying in abundance among benign nevi, primary melanoma, and metastatic melanoma. Seventy-three percent of these proteins were validated by immunohistochemistry staining of malignant melanoma tissues from the Human Protein Atlas database. Our results reveal that molecular pathways involved with tumor cell proliferation, motility, and apoptosis are mis-regulated in melanoma. These data provide the most comprehensive pr.. View More»
  DOI: 10.4172/jpb.1000260

  Abstract PDF

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