Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Samuel G Mackintosh
Tanzania
Research Article
A Proteomic Study of Human Merkel Cell Carcinoma
Author(s): Qiang Shao, Stephanie D Byrum, Linley E. Moreland, Samuel G Mackintosh, Aarthi Kannan, Zhenyu Lin, Michael Morgan, Brendan C Stack Jr, Lynn A Cornelius, Alan J Tackett and Ling GaoQiang Shao, Stephanie D Byrum, Linley E. Moreland, Samuel G Mackintosh, Aarthi Kannan, Zhenyu Lin, Michael Morgan, Brendan C Stack Jr, Lynn A Cornelius, Alan J Tackett and Ling Gao
Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cancer of the skin. The incidence has been quadrupled with a 5-year mortality rate of 46%, presently there is no cure for metastatic disease. Despite the contribution of Merkel cell polyomavirus, the molecular evens of MCC carcinogenesis are poorly defined. To better understand MCC carcinogensis, we have performed the first quantitative proteomic comparison of formalin-fixed, paraffin-embedded (FFPE) MCC tissues using another neuroendocrine tumor carcinoid tumor of the lung as controls. Bioinformatic analysis of the proteomic data has revealed that MCCs carry distinct protein expression patterns. Further analysis of significantly over-expressed proteins suggested the involvement of MAPK, PI3K/Akt/mTOR, wnt, and apoptosis signaling pathways. Our previous study and that from others have shown mTOR activation in MCCs. Therefore,.. View More»
DOI:
10.4172/jpb.1000291