Advancements in Genetic Engineering
Open Access

Sandip Mukherjee

Publications

• Review Article
  Slit/Robo Pathway - Neurogenesis to Cancer Progression: A Potential Therapeutic Target
  Author(s): Arnab Banerjee, Sreeparna Banerjee, Debasmita Das, Bithin Kumar Maji and Sandip Mukherjee Arnab Banerjee, Sreeparna Banerjee, Debasmita Das, Bithin Kumar Maji and Sandip Mukherjee
  
  Slit-Robo could be a cell signaling pathway with numerous functions such as axon steering and ontogenesis. Slit is a secreted macromolecule and most generally referred to as a repulsive axon steering cue, and Robo as its trans-membrane macromolecular receptor. This ligand-receptor combination has been concerned in different kind of neuronal and non-neuronal processes starting from cell migration to ontogenesis, tumorigenesis and organogenesis like kidneys, lungs and breasts, etc. Roundabout receptors (Robo) and their Slit ligands were detected in axon steering. Slit was primarily associate degree extracellular matrix super molecule and expressed by plane interstitial tissue in fruit fly. Slits acted as chemorepellents for axons crossing the plane in vertebrates and invertebrates. The origin of Robo proteins were from fruit fly in an exceedingly mutant screening for genes con.. View More»
  DOI: 10.4172/2169-0111.1000157

  Abstract PDF

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