Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Santiago Mar
Spain
Research Article
Validation of an Experimental Animal Model for Corneal Additive Surgery
Author(s): Lucía Ibares-Frías, Patricia Gallego, Roberto Cantalapiedra-Rodriguez, Maria Cruz Valsero, Santiago Mar, Jesús Merayo-Lloves and Maria Carmen Martínez-GarcíaLucía Ibares-Frías, Patricia Gallego, Roberto Cantalapiedra-Rodriguez, Maria Cruz Valsero, Santiago Mar, Jesús Merayo-Lloves and Maria Carmen Martínez-García
Purpose: To assess the hen cornea as a model for training and future wound healing studies after implantation of intrastromal corneal ring segments (ICRS) by clinical and optical outcomes. Setting: University of Valladolid, Valladolid, Spain. Design: Experimental study. Methods: One 90°, 150-μm thick polymethyl methacrylate Ferrara ICRS segment was manually implanted at 70-80% depth of 192 Gallus domesticus corneas. Clinical follow-up for 6 months included monitoring corneal thickness, epithelial wound closure, edema, haze, and the location and severity of deposits. The refractive state was also measured. After each animal was euthanized, corneas were processed for direct transmittance and histological analysis. Results: Complications were present in 16% of the eyes. Epithelial wound closur.. View More»
DOI:
10.4172/2155-9570.1000360