Autism-Open Access
Open Access

Sara R. Guariglia

Publications

• Review Article
  The BTBR T+tf/J (BTBR) Mouse Model of Autism
  Author(s): Kathryn K. Chadman* and Sara R. Guariglia Kathryn K. Chadman* and Sara R. Guariglia
  
  Mouse models of neuropsychiatric disorders are validated according to three different criteria: face validity, construct validity and predictive validity. Autism Spectrum Disorders (ASDs) are diagnosed behaviorally, therefore, mouse models of ASDs rely primarily on face validity. The three diagnostic criteria for ASDs are impairments in social interaction, communication and repetitive behavior, and/or restricted interests. The BTBR T+tf/J (BTBR) mice are an inbred strain used as model of ASDs. All three types of behavioral criteria have been evaluated in the BTBR mice. An advantage of using an inbred strain, such as BTBR is that, the mice are considered genetically identical and offer good controls for experimentation. The BTBR mice have demonstrated face validity for the three core behaviors that define ASDs. Low levels of social behavior, altered communication and spontaneo.. View More»
  DOI: 10.4172/2165-7890.S1-009

  Abstract PDF

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