Mycobacterial Diseases
Open Access

Sarah A Haines

Publications

• Research Article
  The Treatment of Isoniazid Resistant Tuberculosis with Predominantly a Nine-Month Regimen
  Author(s): Sarah A Haines, Rahul Mittal and Lawrence Peter OrmerodSarah A Haines, Rahul Mittal and Lawrence Peter Ormerod
  
  Background: Chest Clinic in Blackburn UK, a high Tuberculosis (TB) incidence area of the United Kingdom. Methods: Retrospective analysis of a prospectively compiled database of TB notifications. The clinical characteristics and management of those cases with isonazid resistance (with or without additional streptomycin resistance) for the years 1989-2008 inclusive is described. Results: 36 patients with proven and 3 with presumed isoniazid resistance were treated, 15 with pulmonary and 21 with non-pulmonary confirmed cultures. 35 patients (92%) were treated with a regimen of nine months rifampicin and ethambutol, supplemented by two months initial pyrazinamide (2RZE/7RE). No clinical or bacteriological relapses occurred. Conclusion: This retrospective cohort study with a minimum of 12 months pos.. View More»
  DOI: 10.4172/2161-1068.1000151

  Abstract PDF

Relevant Topics